The name CDKN2A stands for "Cyclin-Dependent Kinase Inhibitor 2A." The gene provides instructions for making several tumor suppressor proteins. The 

BackgroundThe diagnosis of malignant pleural mesothelioma (MPM) can be difficult, in part due to the difficulty in distinguishing between MPM and reactive mesothelial hyperplasia (RMH). The tumor suppressor gene, CDKN2A, is frequently silenced by epigenetic mechanisms in many cancers; in the case of MPM it is mostly silenced via genomic deletion.

2012-04-18 2017-12-08 The CDKN2A gene is associated with autosomal dominant melanoma-pancreatic cancer syndrome (MedGen UID: 325450) and melanoma-neural system tumor (NST) syndrome (MedGen UID: 331890). The CDKN2A gene encodes two main proteins, p16INK4a and p14ARF. CDKN2A gene is enough to maintain similar mRNA levels as those in CDKN2A-WT PDAC patients. Interestingly, the CDKN2A-mutant group had higher mRNA levels compared with WT and other groups. It has been suggested that the mutant CDKN2A genes may encode functionally inactivated proteins in cancer cells [26–28]. 2020-05-08 52 cdkn2a Affordable TaqMan Assays for All of Your qPCR Needs CDKN2A-003: ENST00000380151.3: 794: 116aa: ENSP00000369496.3 .

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1998-07-15 The ZytoLight ® SPEC CDKN2A/CEN 9 Dual Color Probe is designed for the detection of p16 deletions by Fluorescence in situ Hybridization (FISH) frequently observed in most tumor cell lines as well as in primary human malignancies. The p16 gene, often referred to as CDKN2A or INK4a/ARF, is located in the chromosomal region 9p21.3. p16 has been identified as a major susceptibility gene for melanoma. The gene CDKN2A may have Genomic and Proteomic products available from Sigma-Aldrich. 2012-04-18 2017-12-08 The CDKN2A gene is associated with autosomal dominant melanoma-pancreatic cancer syndrome (MedGen UID: 325450) and melanoma-neural system tumor (NST) syndrome (MedGen UID: 331890). The CDKN2A gene encodes two main proteins, p16INK4a and p14ARF.

Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation. ARF limited the nucleolar localization of the RNA helicase DDX5. ARF

Mutações no gene CDKN2a estão envolvidas na formação de tumores em  CDKN2A (cyclin dependent kinase 2a / p16) · Description, The gene encompasses 6.6 kb of DNA; 3 exons. · Transcription, 471 nucleotides mRNA. The CDKN2  The Cyclin-dependent kinase inhibitor 2A (CDKN2A) gene encodes several protein isoforms that function as inhibitors of CDK4 and ARF. Missense mutations   CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994.

CDKN2A signals were equally identifiable by AM-FISH and conventional FISH in normal mononuclear blood cells. In contrast, when two BCL cell lines lacking CDKN2A were analyzed, CDKN2A signals were not detected by AM-FISH, whereas conventional FISH yielded false signals.

[7] CDKN2A gene mutations involved in cancer impair production of functional p16(INK4A) or, less commonly, p14(ARF), which can result in uncontrolled cell growth and tumor formation.

CDKN2A expression was correlated with an inferior rate of recurrent disease (p = 0.02).
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The p16 protein controls cell division by binding to CDK4/6. The CDKN2B gene is adjacent to CDKN2A and encodes the p15 (INK4B) protein, which also binds to and inactivates CDK4/6. 2017-12-08 · CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene on chromosome 9. The gene codes for two proteins, both acting as tumor suppressors.

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Functional Associations. CDKN2A has 10,679 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 86 datasets.

Gene aberrations involving the CDKN2A   CDKN2A (cyclin-dependent kinase inhibitor 2A) is a protein-coding gene.