CD137 is expressed in human atherosclerosis, but its role is largely unknown. This study uses a genetic approach to investigate CD137 in human atherosclerotic disease. In publicly available data on genotype and gene expression from the HapMap project, the minor T allele of rs2453021, a single nucleotide polymorphism in CD137, was significantly associated with CD137 gene expression.

av L Söderström · 2016 — By studying gene expression in cell lines, we found an association Human genetic evidence for involvement of CD137 in atherosclerosis.

CD137 was categorized as an early activation gene because the protein synthesis inhibitor, cyclohexamide, blocked formation of its transcripts (Kwon et al., 1987). The nucleotide sequence of CD137 contains a single long open-reading frame, starting with the ATG codon at positions 1-3. CD137 seems to be expressed on antigen-specific activated T cells (Ye et al., 2014) and agonistic antibodies to enhance T cell activity like urelumab have been developed for clinical application. LAG3 and TIM-3 on the other hand seem to limit T cell activity similar to PD-1. CD137, a T cell costimulatory molecule, and its ligand, CD137 ligand (CD137L), which is expressed on antigen presenting cells (APC), are potent drivers of cellular cytotoxic immune responses.

Cd137 gene

memory differentiation (11–13). CD137 (4-1BB, TNFRSF9) is not an exception (14). It gains surface expression on T cells only following TCR-mediated priming (15), although its levels are augmented by CD28 costimulation (16). Ample experimental evidence shows that when CD137 meets its ligand or agonist Construct Details: Full length human 4-1BB/CD137 gene is subcloned into the Lentiviral expression vector pLTC with an upstream CMV promoter, which can be used for both transient and stable expression in mammalian cells. It can be co-transfected with the LentiPAK DNA mix (SKU# LP-001) into HEK293 cells to produce high titer lentiviral particles. CD137 (Tumor Necrosis Factor Receptor Superfamily, Member 9, TNFRSF9) Short Description:The protein encoded by this gene is a member of the TNF-receptor superfamily.

CD137, a T cell costimulatory molecule, and its ligand, CD137 ligand (CD137L), which is expressed on antigen presenting cells (APC), are potent drivers of cellular cytotoxic immune responses. Here, we report that different viruses usurp a negative feedback mechanism for the CD137-CD137L system that weakens cellular immune responses.

2020-10-20 2018-01-01 This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH).

2011-03-18

Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiologic processes and play an important role in the regulation of immune responses. CD137, a T cell costimulatory molecule, and its ligand, CD137 ligand (CD137L), which is expressed on antigen presenting cells (APC), are potent drivers of cellular cytotoxic immune responses. Here, we report that different viruses usurp a negative feedback mechanism for the CD137-CD137L system that weakens cellular immune responses. 2019-11-08 · The tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137 or 4-1BB, is another important immune-modulating molecule known to be expressed on the surface of certain immune cells.

Author : Pär W. (CD137) och CD3 zeta.
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It was first described as a molecule selectively expressed on activated, but not resting, T lymphocytes (1–3). CD137 stimulates the immune system to attack cancer cells and is a key driver for long-lasting T-cell proliferation and survival.

Material and methods: Genes containing anti-CD20-CD28-CD137-TCRζ were constructed. TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers.Gene Ontology (GO) annotations related to this gene … The Human CD137 (4-1BB) Simplex ProcartaPlex Kit measures CD137 (4-1BB) protein and is designed to be combinable with other Simplex kits so that you can create your own multiplex panel that utilizes Luminex xMAP technology for protein detection/quantitation. When combining multiple Simplex kits (i.e 2020-03-24 CD137 stimulates the immune system to attack cancer cells and is a key driver for long-lasting T-cell proliferation and survival.
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CD137 costimulation is a stimulus for effector CD8 T-cell infiltration and persistence within atherogenic foci, regardless of atherosclerotic-antigen recognition. these data point to an important role for 4-1BB, TRAF1, and mTOR in the persistence of CD8 effector T cells in the lung parenchyma, thereby allowing the transition to Trm.

TNFRSF9 gene / cDNA is a protein-coding gene which located on 1p36.23. The TNFRSF9 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.168 organisms have orthologs with human gene TNFRSF9.

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CD137 (Tumor Necrosis Factor Receptor Superfamily, Member 9, TNFRSF9) Short Description:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells.

First, CD137 gene deficiency or blocking of CD137 signaling increased murine susceptibility to G + bacterial infection but made mice more resistant to G − bacterial infection . Second, in G + bacterial infection, stimulation of CD137 by agonistic antibody increased mouse survival, whereas in G − bacterial infection, it diminished mouse survival ( Fig. 2 ).